Greetings PrPs et al,
i am going over old documents of the early days of the BSE Inquiry days to archive again. most of the old links don't work anymore, so i have updated the links. for those that may find interest, you may want to download for future use. this is what it's going to look like in the USA, when CWD TSE PrP in cervid is finally announced that it is a zoonotic zoonosis disease. imo, science has already proven this, but there has been no official announcement of cwd transmitting to humans, yet. NOT DOCUMENTED anyway.
the thing with CWD in cervid, it's much more virulent than c-type BSE in Cattle, with muscle tissue and fat being infectious. see;
Prion Infectivity in Fat of Deer with Chronic Wasting Disease▿
Brent Race#, Kimberly Meade-White#, Richard Race and Bruce Chesebro* + Author Affiliations
In mice, prion infectivity was recently detected in fat. Since ruminant fat is consumed by humans and fed to animals, we determined infectivity titers in fat from two CWD-infected deer. Deer fat devoid of muscle contained low levels of CWD infectivity and might be a risk factor for prion infection of other species.
Prions in Skeletal Muscles of Deer with Chronic Wasting Disease
Here bioassays in transgenic mice expressing cervid prion protein revealed the presence of infectious prions in skeletal muscles of CWD-infected deer, demonstrating that humans consuming or handling meat from CWD-infected deer are at risk to prion exposure.
ENVIRONMENT FACTORS FOR THE TRANSMISSION OF CWD TSE PRP
Sensitive detection of chronic wasting disease prions recovered from environmentally relevant surfaces
Environment International
Available online 13 June 2022, 107347
Research Paper
Cellular prion protein distribution in the vomeronasal organ, parotid, and scent glands of white-tailed deer and mule deer
TUESDAY, MAY 11, 2021
A Unique Presentation of Creutzfeldt-Jakob Disease in a Patient Consuming Deer Antler Velvet
Case Reports
A Unique Presentation of Creutzfeldt-Jakob Disease in a Patient Consuming Deer Antler Velvet
*Joseph Wiedemer, *Yanely Sanchez Ceja, An Cao and Ibrahim Mustafa Department of Neurology, Wright State University Boonshoft School of Medicine, USA Article history
Received: 17-02-2021 Revised: 08-03-2021 Accepted: 13-03-2021
Corresponding Author: Joseph Wiedemer Department of Neurology, Wright State University Boonshoft School of Medicine, USA
Email: Wiedemer.2@wright.edu
*These authors contributed equally to this work and are considered to be co-first authors
Abstract: Creutzfeldt-Jakob Disease (CJD) is a rare rapidly progressive neurodegenerative prion disorder that is usually sporadic but may also be acquired from exposure to infected sources, classically via infections of bovine or human etiology. Cervid transmission of CJD is of particular concern in North America given the rapid spread of Chronic Wasting Disease (CWD)- the Cervid version of CJD. We present a 61-year-old male patient admitted to our service with a one month history of progressive confusion and gait instability, which led to an initial suspicion of Corticobasal Syndrome (CBS) with unusually rapid progression. CJD was also suspected upon learning that the patient began taking deer antler velvet and bovine colostrum supplements roughly two months prior. The diagnosis of CJD was subsequently confirmed by MRI and RT-QuIC CSF assay. Providers should consider Creutzfeldt-Jakob Disease in the differential diagnosis of a patient with cervid exposure and/or in patients with a presentation resembling corticobasal degeneration, especially if symptom onset is rapid. Although it is unclear how this patient acquired CJD, the potential for prion transmission from cervids to humans should be further investigated by the academic community with considerable urgency.
''We believe that our patient’s case of CJD is highly suspicious for cervid etiology given the circumstances of the case as well as the strong evidence of plausibility reported in published literature. This is the first known case of CJD in a patient who had consumed deer antler velvet. Despite the confirmed diagnosis of CJD, a causal relationship between the patient’s disease and his consumption of deer antler velvet cannot be definitively concluded.''
BSE Inquiry Draft Factual Accounts DFAs
Several other accounts will be issued over the next few weeks.
The Inquiry has now completed Phase One (which were purely fact
finding hearings). Phase Two hearings, dealing with potential criticisms,
clarification and conflicts of evidence will begin in late February 1999. The
Inquiry is due to report to Ministers on 30 June 1999.
NOTES TO EDITORS
1. Draft Factual Accounts issued so far:
DFA1: The Southwood Working Party
DFA2: The Tyrrell Committee
DFA3: SEAC
DFA4: CVL (Part 1)
DFAS: Early Days
DFA6: Slaughter and Compensation
DFA7: The Ruminant Feed Ban
DFAS8: Introduction of the SBO Ban
DFA9: Government and Southwood
DFA10: The Introduction of the Animal SBO Ban
DFA11: The Touch Test
DFA12: The ELISA Test
DFA13: The Central Veterinary Laboratory (Part 2)
The Inquiry will issue more draft factual accounts in the next few weeks.
The accounts are available on the Inquiry website www.bse.org.uk and are
available in hard copy from the Inquiry.
1351 Early in the Inquiry, we issued a number of working documents, including a glossary, a dramatis personae and a time-line setting out some of the main events in chronological order. More ambitiously, in December 1998 the Inquiry began to publish draft factual accounts (DFAs) of aspects of the history of BSE and vCJD. The DFAs were placed on our website and sent to witnesses. They were intended to help us clarify the overall picture and to enable all those who were concerned or interested to draw attention to any errors or significant omissions in the drafts. The DFAs were not definitive. We recognised prior to their publication that they could contain errors or omissions. We stressed that DFAs should be treated as no more than working documents, intended to set out relevant evidence in a neutral manner.
1352 Following the publication of the first tranche of DFAs, some witnesses raised concerns with us. They were very concerned that substantial amendment was required and that the original drafts were in places inaccurate or misleading. After considering what they said, we produced revised versions of many of the DFAs, taking account of the comments and additions which witnesses had, as we expected, proposed. The revised versions (RFAs) produced with the help of witnesses and others were considerably improved and this assisted us greatly in establishing the course of events. Further DFAs were published as the Inquiry proceeded. Updates to both the DFAs and RFAs were produced in some cases to deal with comments and to draw attention to further relevant evidence.
1353 We believe that the DFAs, RFAs and updates assisted many of those who were taking an interest in the Inquiry’s work. We could not produce DFAs for all aspects of the story, but where they were produced, they collated a mass of relevant information in a way which enabled it to be digested and reviewed. They also enabled witnesses to refresh their memory of events and identify evidence upon which they wished to comment.
1354 In June 1998 we published a document setting out our understanding of government structures for scientific research. This was followed in 1999 by discussion papers inviting comments on issues relating to the role of the advisory committees, particularly SEAC, and on epidemiology. When the hearing of oral evidence drew to a close, we issued a more general invitation to supply any further comments anyone wished to make.
Draft Factual Accounts are not intended to cover all the areas of evidence, to make any judgements about the implications of the facts or to point to any conclusions. The DFAs are intended to help the Committee in the current phase of their work, which is concerned to clarify the overall picture by further investigation of evidence. DFAs are also intended to assist all who are involved with the Inquiry. Each DFA seeks to set out an account of facts relevant to its topic, taking account of material in the Inquiry's Hearing Bundles prior to the date of issue. On occasion, areas where clarification is required may be specifically identified. Please note that the DFAs are not definitive. They may contain errors or omissions. Existing evidence as to the facts may be re-evaluated, and further evidence relevant to the facts may be received. For all these reasons, DFAs should be treated as no more than working documents. Please note that due to the size of the documents, it can take up to 30 minutes on a standard internet connection to download. It is therefore recommended that you download them to your local PC before reading them. Please note that to view the Word versions it is recommended that you view them in Page layout mode. Cover sheets are now available for RFAs 1, 9 and DFAs 18, 23, 25. These cover sheets give details of where further relevant evidence for the RFA/DFA can be found, and if appropriate, list any revisions since publication of the most recent update (if any). |
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DFA 26
Public Pronouncements by the CMO, May 1990
29 November 1999
DFA 25
Notification of the Ruminant Feed Ban to non-EC countries
4 November 1999
DFA 24
Public Pronouncements by the CMO on the human heath implications of BSE, March 1993 and June 1993
6 December 1999
DFA 23
Maff statements in 1990 about a cat with a spongiform encephalopathy
16 November 1999
DFA 22 MIA
DFA 21
Cattle Tracking
23 November 1999
DFA 20
Introduction of the ruminant feed ban and compulsory notification of BSE in Northern Ireland
3 December 1999
DFA 19
Dissection of Bovine Eye balls
8 November 1999
DFA 18
Cosmetics
29 October 1999
DFA 17
Medicines and medical devices
7 October 1999
DFA 16
Mid 1995 to the final days
7 July 1999
DFA 15
Monitoring and Enforcements of the SBO Regulations
9 July 1999
DFA 14
Consideration of the Risk from Mechanically Recovered Meat (MRM) in 1989
9 July 1999
BSE Inquiry Issues Factual Accounts.
BSE Inquiry Issues more Factual Accounts, 22nd January 1999.
BSE Inquiry Issues more Factual Accounts, 26th January 1999.
terry
